In this episode we discuss a report from the Hartwig lab on an enantioselective hydroamination reaction. Through rational catalyst design, a cationic iridium complex was discovered that adds an amine N–H bond across a range of unactivated, internal alkenes. DOI: 10.1038/s41586-020-2919-z Xi, Y.; Ma, S.; Hartwig, J. F. Catalytic asymmetric addition …

In this episode we interview Mark Levin, an Assistant Professor at UChicago. We discuss his recent publication with the Jacobsen group, life as a new professor, and places to eat in Chicago.

In this episode we discuss a report from the Jacobsen lab on an enantioselective synthesis of difluorinated alkyl bromides catalyzed by a chiral iodoarene. Linear free energy relationships between experimental enantioselectivities and computed catalyst parameters helped elucidate the origins of enantioselectivity. DOI: 10.1021/jacs.0c07043…

In this episode we interview Marshall Brennan, the founder and Senior Product Manager of ChemRxiv. We discuss open-access publishing, alternative chemistry careers, and much more.

In this episode we interview Dr. Daniele Leonori, who is a professor of chemistry at the University of Manchester. We discuss his recent paper on dehydrogenative aniline synthesis, differences between the UK and US academic system, and much more.

In this episode we discuss a report from the Leonori lab on a photochemical dehydrogenative strategy for aniline synthesis. Photoredox and cobalt catalysis are combined to transform cyclohexanones into anilines. DOI: 10.1038/s41586-020-2539-7

In this episode we interview Dr. M. Christina White, who is a professor of chemistry at the University of Illinois. We discuss her recent paper on C–H methylation as well as her program on site-selective C–H oxidation chemistry.

In this episode we discuss a report from the White lab on a new method for late-stage C–H methylation adjacent to heteroatoms. DOI: 10.1038/s41586-020-2137-8

In this episode we discuss the total synthesis of (–)-maximiscin reported by the Baran lab. The route takes advantage of a convergent fragment coupling strategy with a late-stage formation of the central pyridone ring. DOI: https://doi.org/10.1021/jacs.0c03202

In this episode we discuss a report from the Knowles lab on a method for catalytic deracemization using visible light. This strategy benefits from two independent stereoselective steps resulting in a highly enantioselective transformation. DOI: 10.1126/science.aay2204.

In this episode we interview Jake Yeston, who is Science's editor for physical sciences research.

In this episode we discuss the total synthesis of (+)-perseanol reported by the Reisman lab. The route proceeds in 16 steps and takes advantage of a convergent fragment coupling strategy. DOI: https://doi.org/10.1038/s41586-019-1580-x

In this episode we interview the authors of a new paper on catalyst-controlled silver-catalysed nitrene transfer. By changing the ligand on silver the catalyst selectively functionalizes beta or gamma C-H bonds to form amino alcohols. Link: https://rdcu.be/bQGsf

In this episode we analyze a new paper from the Denton lab where they report a redox-neutral organocatalytic Mitsunobu reaction eliminating the need for stoichiometric, hazardous reagents. DOI: 10.1126/science.aax3353

In this episode we analyze a set of papers from the Ritter lab where they describe a new methodology for highly selective C–H functionalization reactions. Using thianthrenium salts as a synthetic linchpin, the Ritter lab demonstrates para selective amination, trifluoromethylation, and C–C cross-coupling reactions each in an effective two-step synth…

In this episode we analyze a paper from the Lambert lab where they report a new catalyst which upon electrochemical oxidation and photochemical excitation becomes a potent oxidant. The authors apply this strategy to coupling arenes and nitrogen heterocycles. DOI: 10.1002/anie.201906381

In this episode we analyze the total synthesis of arcutinidine developed by the Li lab and compare it to recent syntheses completed by the Sarpong and Qin labs.

In this episode we discuss a new paper from the Schoenebeck lab where they report a new method to couple aryl iodides and chiral phosphorothioate salts using Pd(I) dimer catalysis.

In this episode we analyze a new paper from the Kwon lab where they report a deconstructive strategy to access chiral synthetic intermediates starting from terpene and terpenoid derived precursors. DOI: 10.1126/science.aaw4212

In this episode we discuss a recent report from the Leonori lab on a new method for carbon-nitrogen bond formation by direct reaction of arenes and alkyl amines using photocatalysis. DOI: https://doi.org/10.1038/s41557-019-0254-5

Introducing The Cyclo Edition—the podcast for those looking to go above and beyond in their understanding of organic literature. Episodes will be released every other week starting June 10.