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Featuring articles on lenvatinib plus pembrolizumab in renal cell cancer, oxygenation targets for acute respiratory failure, cardiovascular risk and glycemic index, sutimlimab in cold agglutinin disease, extending life span in a mouse model of progeria, and overcoming Covid vaccine hesitancy; a review article on vestibular schwannomas; a case repor…
 
Welcome to another episode of Curbside Consults! As part of our series on Inclusivity in Medicine and to honor Women’s History Month, we are focusing on women in clinical trials. We are joined by Dr. Janine Clayton, an ophthalmologist and Director of the National...NEJM Group
 
Featuring articles on adjuvant nivolumab in esophageal cancer, sotatercept for pulmonary arterial hypertension, lumasiran for primary hyperoxaluria type 1, upadacitinib for psoriatic arthritis, and an Ebola relapse leading to transmission; a review article on glucose-lowering drugs to prevent cardiovascular disease; a Clinical Problem-Solving on st…
 
Featuring articles on the efficacy of the ALVAC–gp120 HIV vaccine, a JAK inhibitor or interleukin-4 blockade for atopic dermatitis, semaglutide for nonalcoholic steatohepatitis, enfortumab vedotin for relapse of urothelial cancer, the link between cancer and obesity, and embracing genetic diversity to improve Black health; a review article on atopi…
 
Featuring articles on once-weekly semaglutide in adults with overweight or obesity, neutralizing antibodies to prevent HIV-1 infection, passive immunotherapy in patients with Covid-19, inhibition of C3 in paroxysmal nocturnal hemoglobinuria, and the political nature of sex; a review article on extrahepatic manifestations of chronic HCV infection; a…
 
Featuring articles on a randomized trial of gestational diabetes screening, a neutralizing monoclonal antibody for hospitalized patients with Covid-19, risdiplam in type 1 spinal muscular atrophy, genome sequencing in myeloid cancers, a cautionary note about round spermatid injection, and supplying insulin while evading immunity; a review article o…
 
As part of our Curbside Consults series on Inclusivity in Medicine, we are joined by Dr. Sarah Kimball to discuss the relation among healthcare systems, social distance, and migrant patients. Dr. Kimball is an Internist and Assistant Professor at Boston University School of Medicine...NEJM Group
 
Featuring articles on baricitinib plus remdesivir for adults with Covid-19, albumin infusions in patients with cirrhosis, a trial of terlipressin for hepatorenal syndrome, nivolumab plus cabozantinib in renal-cell carcinoma, and on misrepresenting race; a review article on diffuse large B-cell lymphoma; a Clinical Problem-Solving describing a treac…
 
In this episode of Curbside Consults, we discuss the diagnosis and management of primary, secondary, and tertiary hyperparathyroidism with Dr. O.P. Hamnvik, who is an endocrinologist and educator at the Brigham and Women’s Hospital in Boston and the NEJM Group...NEJM Group
 
As part of our “Inclusivity in Medicine” series of Curbside Consults, we are joined by Dr. Samantha Meints, Clinical Pain Psychologist in the Department of Anesthesiology and Pain Medicine at Brigham and Women's Hospital, to discuss racial disparities in the assessment...NEJM Group
 
Inhibitors of sodium–glucose cotransporter 2 (SGLT2) are known to improve cardiovascular and renal outcomes in patients with type 2 diabetes. Until recently, less was known about the effects of SGLT2 inhibitors on heart failure. In this episode of Curbside Consults, we...NEJM Group
 
Apologies for the long silence. We have been off doing other things — one of which has been figuring out how to cover conferences. Last month, after much preparation, we covered the American Society of Hematology (ASH) annual conference; our second foray consists of brief coverage of the American Society of Clinical Oncology (ASCO) gastrointestinal…
 
The COVID-19 pandemic has exposed the magnitude of health inequities that exist today. In this Curbside Consults as part of our “Inclusivity in Medicine” series, Dr. Jim O’Connell, President of the Boston Healthcare for the Homeless Program joins us to discuss how the...NEJM Group
 
Patients who clinically deteriorate on medical and surgical wards suffer substantial morbidity and mortality. Identifying patients who are at risk for clinical deterioration provides an opportunity for early intervention. Complex automated models that use the vast data...NEJM Group
 
Obesity is a major cause of morbidity in the United States and many other high-income countries. Its association with diabetes, hypertension, cardiovascular disease, and ultimately reduced life expectancy is well known. A healthy diet and regular exercise can prevent...NEJM Group
 
In this special episode of Curbside Consults, we interview Dr. Elissa Falconer, the team leader of the NEJM Resident 360 QI Challenge winning submission. Dr. Falconer is a general surgery resident at Atlanta VA Healthcare System. The title of their quality improvement...NEJM Group
 
Eric Rubin is editor-in-chief of the New England Journal of Medicine. I asked him how COVID-19 has affected that journal, which has been around since the War of 1812 and seen its share of pandemics. Listen in — it’s the first in a planned series of interviews with the editors of the principal clinical journals. Running time: 19 minutes NEJM’s Covid…
 
The coronavirus pandemic has meant that for one of the first times ever, the entire world is experiencing the same thing at the same time. It has given me pause to think though, isn’t this exactly what climate change has been trying to highlight all along- that climate...NEJM Group
 
Dr. Paul Sax writes the closest thing that the NEJM Group has to humor. He’s serious, of course, since his blog “HIV and ID Observations” concerns all things infectious . But he sprinkles in the odd cartoon or links to … dog videos, fer cryin’ out loud. He scours the ID literature (and we must include the social-media literature in that category) f…
 
Back in late March (people often tell me that, these days, 4 months ago might as well be 4 years ago) we talked with emergency physician Julian Flores, who was working out of Broward County. Covid-19 cases were modest in number but threatening to get worse, and indeed they did. The county’s cases jumped 100-fold, from about 600 to over 50,000. Just…
 
Don’t expect HIPAA regulations to protect your “digital health footprint” from prying eyes. Every time you swipe your card to buy goodies at the supermarket (are you risking diabetes with all that ice cream?), or binge-watch that kinky series (how’s your mental health these days, really?), or let your step-tracker show you’ve fallen off the pace (c…
 
The COVID-19 pandemic has forced innovation in health care in many ways, one of which is putting to test advances in digital health. There has been no better time to test its value than in this environment of social distancing, reduced contact, and heightened health...NEJM Group
 
We interview Dr. Michael Gonzalez, a Houston-based emergency physician, who describes the situation there as “an ongoing, slow-rolling, level 6 hurricane that just isn’t gonna go away and, more importantly, isn’t gonna tell us when landfall is coming and when it’s gonna be over.” How are his patients reacting to this surge? What does he do to prepa…
 
This time Dr. Ali Raja and Joe Elia talk with two authors of a study that found disparate effects on traffic deaths from the legalization of recreational cannabis. The two states under study, Colorado and Washington, were compared, not with each other, but with a composite of states that most closely resembled what Colorado and Washington would be …
 
In this episode of Curbside Consults: Statistical Review, we explore the interpretation of secondary outcomes in clinical trials using the following two articles recently published in NEJM: Bonaca MP et al. Rivaroxaban in Peripheral Artery Disease after Revascularization...NEJM Group
 
In today’s podcast we are joined by Dr. Marc Bonaca to discuss the findings of the recent VOYAGER PAD trial and the use of low-dose rivaroxaban in peripheral artery disease after revascularization.NEJM Group
 
The novel coronavirus obviously has devastating effects on the lungs, but other, less immediately visible attacks occur — notably to the kidneys. Dr. Steven Fishbane (a nephrologist) and his colleagues have just published their findings based on a survey of some 5500 patients with COVID-19 admitted to a metropolitan New York health system. Acute ki…
 
A combination of three antivirals — Kaletra (which is lopinavir plus ritonavir) and ribavirin — when given early and with interferon significantly reduces viral shedding, disease symptoms, and hospital stay in patients with COVID-19 when compared with a control regimen of Kaletra alone. The drugs are active against other coronaviruses, but the key …
 
We (Dr. Danielle Bowen Scheurer and Joe Elia) talk with Dr. John Jernigan of the CDC COVID-19 Investigation Team, which recently published its findings on the spread of COVID-19 in a Seattle-area skilled nursing facility. Most intriguingly, over half the patients who tested positive were asymptomatic at the time of their first testing, and a few ha…
 
Cardiovascular consults are way down. Is the threat of COVID-19 infection scaring people away from EDs? We caught up with Dr. Comilla Sasson, the American Heart Association’s VP for science and innovation. She’s an emergency physician who teaches at the University of Colorado. She’d traveled to New York City to “help with the response,” and she […]…
 
In this episode of Curbside Consults, we continue our exploration of the prescription and use of opioids in the treatment of chronic pain. We hear a patient’s point of view, exploring how a patient with chronic pain manages his relationship with his provider, pharmacy, and...NEJM Group
 
This week’s guests, Dr. Andre Sofair and Dr. William (“Rusty”) Chavey are physician-editors on the daily clinical news alert called Physician’s First Watch. I went back through the recent issues and found this January 10 entry, which began “The CDC is requesting that clinicians ask their patients with severe respiratory disease about any travel to …
 
Four weeks ago — in early March — I interviewed Dr. Renee Salas about climate change and clinical medicine. Back in those halcyon days, COVID-19 was very much a gathering storm, but it had not yet slammed into the United States. Here we are, over 10,000 U.S. deaths later in early April, not having heard of much […] The post Podcast 257: Here comes …
 
In this statistical review episode of Curbside Consults, we explore descriptive epidemiology studies of the COVID-19 outbreak using an article by Guan and colleagues published online in NEJM on February 28, 2020. To help explain the approach to outbreak study analysis...NEJM Group
 
We talk with Colleen Farrell who’s doing her third year of an internal medicine residency in New York City. Fortunately, we caught her during a one-week vacation (she was supposed to be taking two), and she chatted with us about how she and her colleagues are coping. We asked her what she thought COVID-19’s larger lessons would […] The post Podcast…
 
San Diego County has Dr. Kristi Koenig as medical director of its emergency medical services. That’s fortunate for the county, because she’s co-edited a definitive textbook, “Koenig and Schultz’s Disaster Medicine: Comprehensive principles and practices.” We’re fortunate to have her as our guest. She’s full of sound advice on organizing a community…
 
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