This podcast by Mathias Pickl and Christoph Winkler officially accompanies the Biotrans 2021 conference in Graz. Meet here the scientists who were invited to give a lecture at the meeting and are among the brightest minds in the field. Talking science without graphical aids gives a unique opportunity to address a broader perspective and to get to know the researchers in a new way. (The Podcast "In the Active Site" is released under a CC-BY license)