Fructose IBS, HIGH IGF-1 and Cancer, Lifting and Joint Health | THRR073

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Fructose Malabsorption and IBS, High IGF-1 and Prostate Cancer, Air Purifiers, Lymphocytic Colitis and Heart Palpitations/Extreme Anxiety/Brain Fog, Heavy Lifting on Joints

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Reframing Nutritional Microbiota Studies To Reflect an Inherent Metabolic Flexibility of the Human Gut: a Narrative Review Focusing on High-Fat Diets

"While human metabolism can adapt to diets higher in either fats or carbohydrates, the natural diet of a mouse is low in fat and high in carbohydrates. It is therefore unsurprising that mice develop issues when eating a species-inappropriate diet. The strain of mice commonly used for such studies, C57BL/6, has also been genetically selected for its ability to gain weight in response to a HF diet. While humans are capable of weight loss or gain on a variety of dietary patterns (32–34), C57BL/6 mice have greater weight gain and metabolic disruptions on low-carbohydrate diets (35). Consequently, “…rodent models of obesity may be most valuable in the understanding of how metabolic mechanisms can work in ways different from the effect in humans” (35). Broadly translating findings from inbred mice fed a highly refined HF diet to humans is therefore fraught with potential for misunderstanding."

1. Fructose Malabsorption and IBS [23:57]

Jack says:

Hi Robb,

I've been experiencing IBS over the past few years, awful cramping and diarrhea. I finally decided to have a food sensitivity test done, and have a fructan & fructose malabsorption. The GI specialist didn't really give me any direction or recommendations, only a diagnosis.

I would like to try and do a paleo/primal diet, but low in fructose/fructans. This leaves me with a pretty limited choice on fruits and veggies that sit well with me. I love the way veggies taste and the way they make me feel.

Do you have any suggestions for me? I found a supplement called FRUCTAID (Glucose Isomerase Enzyme) that helps. Do you recommend I just take that with every meal high in fructose/fructans?

Should I be taking a greens powder and a multivitamin to make sure and get all the good stuff and just eat what I can and skip the FRUCTAID? Worried that I will get palate fatigue and become deficient in some nutrients by eating this way. I could be overthinking this, but its all pretty new to me.

Thanks,

Jack

2. High IGF-1 and Prostate Cancer [27:35]

Eric says:

Hi All,

In the fall of 2021, I went through an early stage prostate cancer treatment that included radiation, brachytherapy, and androgen deprivation. Fun stuff. I'm getting my androgens back, slowly but surely, making "morning wood" a thing again. Hooray for me! I'm taking my chances with a high protein, low glycemic approach to eating to help prevent the cancer from coming back. I'm likely in and out of ketosis on a daily basis depending on when I ate my last meal. I keep under 25 carbs, and eat 205 grams of protein a day. I'm 5'10, 232lbs, and right around 22-23% body fat. I'm also 40 years old. I weight train 4-5 times per week, and roll jiujitsu 3x per week.

Since I've heard of the relationship between IGF-1 and prostate cancer, my question pertains to it. At 40, my IGF-1 levels are around 337ng/dl. That's about 100ng/dl over what my high point "should" be at this age (I'm great for a teenager but without that level of morning wood). This stays true regardless of whether I'm insulin sensitive or not. I tested before my androgen deprivation therapy and my fasting insulin was 5uIU/ml. At the height of the deprivation my fasting insulin was 15 and the igf-1 was 357. Now my fasting insulin it has begun to drop back to within the 8-10 range, going down, and the IGF-1 levels remain about the same. We don't think I have a benign pituitary tumor, which would be nice to not have brain surgery; but we are testing for that despite my mri coming back negative. My question, then, is twofold: is this something to worry about, or would you take these levels to be "normal" given my athletic endeavors, pretty large frame, and protein intake? If you think it's something to worry about, do you have any strategies I might suggest to my doctor for eeking out some answers?

Carbohydrate Restriction, Prostate Cancer Growth, and the Insulin-Like Growth Factor Axis

Nutritional Predictors of Insulin-like Growth Factor I and Their Relationships to Cancer in Men

"Men with relatively high intakes of total protein (top quintile) and minerals (top quintile of the five minerals combined) had a 25% higher mean plasma level of IGF-I compared with those in the low quintiles simultaneously. The major sources of animal protein, including milk, fish, and poultry, but not red meat, as well as total vegetable protein, were associated with an increase in IGF-I levels. Energy intake was positively related to plasma IGF-I level but only in men with body mass index