Blood Advances, a Journal of the American Society of Hematology, provides an open international forum for the publication of original articles describing basic laboratory, translational, and clinical investigations in hematology and related sciences. Music for Blood Advances Talks is preformed by the Art Topilow Trio
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GRNDaD: big data and sickle cell disease
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Big data are used in the pursuit of precision medicine in the general population. Applying these tools to patients with sickle cell disease (SCD) is essential for ensuring that they receive the most appropriate customized therapy for their disease. For these tools to be applied, there must be a large number of willing, fully phenotyped participants…
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Investigational curative gene therapy approaches to sickle cell disease
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Sickle cell disease (SCD) is an inherited blood condition resulting from abnormal hemoglobin production. It is one of the most common genetic diseases in the world. The clinical manifestations are variable and range from recurrent acute and debilitating painful crises to life-threatening pulmonary, cardiovascular, renal, and neurologic complication…
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Why is AAV FVIII gene therapy not approved by the US Food and Drug Administration yet?
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The prospect of a clinical strategy using an adeno-associated virus (AAV) vector for expression of therapeutic levels of factor VIII (FVIII) has been highly desirable. This was initially anticipated by promising data from clinical studies on AAV5-FVIII in men with severe hemophilia A. However, long-term follow-up showed a unique efficacy concern on…
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Thrombosis and novel hemophilia therapies: the fine line between clotting and bleeding
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The availability of novel nonfactor therapeutics is revolutionizing the management of hemophilia in individuals with inhibitory antibodies, as well as making prophylaxis more convenient even in the absence of inhibitors. Unfortunately, the use of these products has been associated with thrombotic events that are not typically seen with factor repla…
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Concizumab: a novel anti-TFPI therapeutic for hemophilia
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Amy Shapiro discusses the recent approval of concizumab for the treatment of patients with hemophilia. This novel subcutaneous homeostatic rebalancing agent has proven to be useful for the treatment of patients with hemophilia A and B, and we hope you find this talk to be useful to understand it.Blood Advances Talks
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Naive T-cell depletion in stem cell transplantation
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Allogeneic hematopoietic stem cell transplantation (HCT) is curative in many patients with advanced hematopoietic malignancies. Donor T cells not only facilitate engraftment and protect against opportunistic pathogens and residual disease, but can also cause graft-versus-host disease (GVHD), with significant morbidity and mortality.…
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The management of venous thromboembolism in hospitalized patients with COVID-19
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The high incidence of thromboembolic disease, and in particular venous thromboembolism (VTE), has emerged as an important consideration in hospitalized and critically ill patients with coronavirus disease 2019 (COVID-19).Blood Advances Talks
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Gene therapy for hemophilia: anticipating the unexpected
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The treatment of hemophilia, which has undergone many transformative changes over the past 60 years, is poised for yet another disruptive change: the use of gene therapy to produce functional cures in some persons with hemophilia A or B.Blood Advances Talks
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The changing landscape of anticoagulation in cancer-associated thrombosis
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The changing landscape of anticoagulation in cancer-associated thrombosisBlood Advances Talks
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TA-TMA: state of the art for diagnosis and treatment
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Blood Advances Talks
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Inherited predisposition to myeloid malignancies
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Inherited predisposition to myeloid malignancies by Blood Advances TalksBlood Advances Talks
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Managing patients who are receiving warfarin (or DOAC)and need an elective surgery or procedure
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Managing patients who are receiving warfarin (or DOAC)and need an elective surgery or procedure by Blood Advances TalksBlood Advances Talks
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Daily light-and-darkness onset regulates mouse hematopoietic stem cells
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Daily light-and-darkness onset regulates mouse hematopoietic stem cells by Blood Advances TalksBlood Advances Talks
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Extended therapy for unprovoked venous thromboembolism: when is it indicated?
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Extended therapy for unprovoked venous thromboembolism: when is it indicated? by Blood Advances TalksBlood Advances Talks
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Antiplatelet therapy in the management of atherothrombosis: recent clinical advances
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Antiplatelet therapy in the management of atherothrombosis: recent clinical advances by Blood Advances TalksBlood Advances Talks
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Challenges facing the benign hematology physician-scientist workforce by Blood Advances TalksBlood Advances Talks
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Choosing for whom to recommend allogeneic transplantation for AML in CRL
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Choosing for whom to recommend allogeneic transplantation for AML in CRL by Blood Advances TalksBlood Advances Talks
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Catalyzing innovation in clinical trial design and analysis at NHLBI
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Catalyzing innovation in clinical trial design and analysis at NHLBI by Blood Advances TalksBlood Advances Talks
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ITP and thrombosis: an intriguing association
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ITP and thrombosis: an intriguing association by Blood Advances TalksBlood Advances Talks
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The current therapeutic landscape of FLT3 inhibitors
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The current therapeutic landscape of FLT3 inhibitors by Blood Advances TalksBlood Advances Talks
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How many mice? Design considerations for murine studies
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How many mice? Design considerations for murine studies by Blood Advances TalksBlood Advances Talks
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The Direct Oral Anticoagulants – can we finally stop using rat poison?
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The Direct Oral Anticoagulants – can we finally stop using rat poison? by Blood Advances TalksBlood Advances Talks
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Impact of the ICAL on the treatment of acute leukemia
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Impact of the ICAL on the treatment of acute leukemia by Blood Advances TalksBlood Advances Talks
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Venetoclax: a primer by Blood Advances TalksBlood Advances Talks
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Technological Solutions For Global Hematology And Oncology
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Technological Solutions For Global Hematology And Oncology by Blood Advances TalksBlood Advances Talks
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The Lucky Iron Fish: a simple solution for iron deficiency
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The Lucky Iron Fish: a simple solution for iron deficiency by Blood Advances TalksBlood Advances Talks
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New developments in the management of sickle cell disease
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New developments in the management of sickle cell disease by Blood Advances TalksBlood Advances Talks
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Should we avoid heparin to eliminate HIT?
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Should we avoid heparin to eliminate HIT? by Blood Advances TalksBlood Advances Talks
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