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Modern Healthspan
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Modern Healthspan

Modern Healthspan

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Our channel provides longevity, anti-aging and health information. We interview experts in their field to get the latest information in the longevity space. You can also come to our YouTube channel for more information here https://www.youtube.com/channel/UCLFEKx_LchTLy_XwjPToJ3A
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Agingdoc Podcast interviews longevity doctors and geroscientists to find and expedite healthspan and life extension for all. http://agingdoc.com (Barzilai Consulting). I serve as a concierge longevity health coach (Online calendar to book phone consults at agingdoc.com) and on X (@agingdoc1) and YouTube (http://youtube.com/@agingdoc) I provide free content away from the hype, buzz and misinformation proliferating on social media. I accept no sponsorship nor affiliate marketing. My audience i ...
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Here Dr Gibala talks how to think about exercise routines and nutrition as well as sharing his own protocol and the current work of his lab Dr Martin Gibala is a Professor at McMaster University where his research examines the effects of exercise at the molecular to whole body level in both healthy individuals and people with chronic diseases. In a…
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Credit: Hevolution Foundation clip - support them at Hevolution.com Stay tuned... this gets *really* good. Not only great moments in geroscience (aging biology). But great moments in moderation! More at https://www.youtube.com/watch?v=0KT9v_NFfak Thank you Hevolution Foundation: BRAVO! PS- Much better visuals at http://youtube.com/@agingdoc , why n…
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Here Dr Gibala talks about what is VO2max, why it is important, how to measure and improve it. Dr Martin Gibala is a Professor at McMaster University where his research examines the effects of exercise at the molecular to whole body level in both healthy individuals and people with chronic diseases. In addition to basic, mechanistic studies on the …
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Here we discuss some themes on @agingdoc at @YouTube . This is part of "Project 49" my committment to myself on my 49th birthday to branch out and apply knowledge and skills in longevity medicine and aging biology towards a broader healthspan moonshot for all. Find me at: agingdoc.com healthspancoaching.com / barzilaiconsulting.com youtube.com/ @ag…
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@agingdoc [ agingdoc.com longevity coach] interview with Aubrey de Grey, PART 2. This is an interview with Aubrey unlike any other. A great time for both of us. It's a lively deep dive into controversy and Aubrey's rebuttals and paradigms for change. You be the judge: 🔑 KEY INTERVIEW MOMENTS BELOW :👇🔎🧐 00:00 Setting the stage our deep-dive 02:44 Au…
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Here Dr Gibala introduces interval training and discusses the various styles, and the benefits. Dr Martin Gibala is a Professor at McMaster University where his research examines the effects of exercise at the molecular to whole body level in both healthy individuals and people with chronic diseases. In addition to basic, mechanistic studies on the…
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Today's epsiode is in the spirit of the first Agingdoc Longevity Walk and Meetup, tomorrow 11/20/23 in NYC (Monday 11/20/23, 6pm meeting at The Dakota. Details: https://x.com/agingdoc1/status/1725527792282910895?s=20 Best, David ( "Agingdoc" ). Links: Agingdoc.com ( More info & Longevity Coaching scheduling) Agingdoc Podcast on Youtube (Video) Agin…
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Here Dr Patel talks about his topical glutathione treatment Glutaryl and the recent trial that was conducted at McGill University. Dr. Nayan Patel is an alumnus of the University Of Southern California School Of Pharmacy, where he now serves as adjunct faculty. A pharmacist for over three decades, Patel is an internationally recognized expert, cons…
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Here Dr Patel talks about the changes that happen with glutathione as we age, why it is important and what we can do to restore the levels. Dr. Nayan Patel is an alumnus of the University Of Southern California School Of Pharmacy, where he now serves as adjunct faculty. A pharmacist for over three decades, Patel is an internationally recognized exp…
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Here Dr Patel talks about glutathione's major two functions in the body, as an antioxidant and a detoxifier. He also discusses measuring our glutathione levels and what would be a good value to aim for. Dr. Nayan Patel is an alumnus of the University Of Southern California School Of Pharmacy, where he now serves as adjunct faculty. A pharmacist for…
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Here Dr Conlon talks about her personal protocol, that she has decided on as a data driven scientist. We also discuss the next steps for Nuchido as a longevity company. Dr Nichola Conlon is a molecular biologist specialising in the study of cellular aging. After a career in drug development, she founded Nuchido Laboratories to deliver disruptive in…
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Here Dr Conlon talks about the human trial that she sponsored to evaluate the benefits of Time+ on humans. Dr Nichola Conlon is a molecular biologist specialising in the study of cellular aging. After a career in drug development, she founded Nuchido Laboratories to deliver disruptive innovation in the field of aging, rejuvenation and healthspan. D…
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Here Dr Conlon talks through all the components of Nuchido Time+ and how they fit into the strategy of restoring NAD by activating the cell's natural mechanisms. Dr Nichola Conlon is a molecular biologist specialising in the study of cellular aging. After a career in drug development, she founded Nuchido Laboratories to deliver disruptive innovatio…
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Aubrey de Grey was my very first guest of the Agingdoc Podcast (before I even gave it a name or was known to be the person behind @,agingdoc1 on Twitter / X) and I think of both Aubrey and Matt Kaeberlein as "Fathers" of the podcast ( with "Mothers to come"). These two were recorded essentially the same time and kicked off this podcast series, each…
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Agingdoc interviews Matt Kaeberlein We're just getting warmed up, in this multi-part interview. Matt and I spent 4.5 hours together and I'll be sharing some of the most enlightening moments. Be sure to subscribe not to miss a future release and search for Agingdoc Podcast on Youtube for the best experience: Video edition at http://youtube.com/@agin…
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🔑Don't miss the footnotes/credit at the bottom! 00:00:00 Introduction @TheSheekeyScienceShow (check out Eleanor's channel!) 00:02:17 Eleanor asks: "Who exactly are you?" 🧐 00:02:37 What am I going to do [for a career]?! 🥼 00:04:51 ME: “I thought a lot of doctors were pretty terrible…”🤯 00:05:43 The Biopsychosocial Model. 📖 00:06:50 Yes, I wrote to …
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Here Dr Conlon explains the biochemistry behind Nuchido Time+ and how it activates the salvage pathway through NAMPT to replenish cellular NAD in sustainable way. Dr Nichola Conlon is a molecular biologist specialising in the study of cellular aging. After a career in drug development, she founded Nuchido Laboratories to deliver disruptive innovati…
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Agingdoc Podcast overview: This short clip provides a snapshot of what makes this podcast unique in the areas of geroscience, longevity, and lifestyle medicine. It's an off-the-cuff overview by myself (@agingdoc) as a snapshot of my goals and what I hope to do. These videos are an archive of an early stage of "project 49" going public after being h…
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Here Professor Gorbunova about the naked mole rat and bowhead whale and what adaptions they have to enable them to live longer. From this she discusses how these adaptions might be translated into interventions for humans. Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, she identified high molec…
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Here Professor Gorbunova talks about hyaluronic acid, what it is and why it is different in naked mole rats. She also talks about a trial that she performed where the gene for HA was placed in mice. Finally we talk about how this could be translated into clinical usage. Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the Un…
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Here Professor Gorbunova talks about the two functions of SIRT6, deacetylation and ribosylation, the importance of them and how they can be activated. She also touches on chromatin remodeling and Yamanaka factors. Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, she identified high molecular weig…
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Here Professor Gorbunova talks about the key activities of SIRT6 that are involved with longevity, particularly DNA repair and the suppression of transposons. Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, she identified high molecular weight hyaluronan as the key mediator of cancer resistance …
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In this video Dr Wang talks about the current state of trials and how the therapy might eventually look. Stan Wang is Founder and CEO of Thymmune Therapeutics, a cell therapy company working to address high unmet needs across immunology. Previously, Stan was Founding Chief Scientific Officer at Cellino Biotech, where he led R&D and application of i…
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In this episode Dr Wang explains about the thymus gland and his technology for not only restoring the thymus but building new thymuses from iPCSs at scale. Stan Wang is Founder and CEO of Thymmune Therapeutics, a cell therapy company working to address high unmet needs across immunology. Previously, Stan was Founding Chief Scientific Officer at Cel…
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Here Dr Tan talks about tocotrienols in bone health, what an appropriate dosage is and it is better not to take alpha tocopherol with the tocotrienols. Dr. Barrie Tan was formerly an assistant professor at the University of Massachusetts in Amherst (Chemistry, Food Science & Nutrition). His mission at American River Nutrition is to deliver the high…
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Here Dr Tan talks about the trails that have been run on tocotrienols and the results that have been seen. They have beneficial effects on a number of the markers of metabolic syndrome, such as the lipid panel and liver fat. Dr. Barrie Tan was formerly an assistant professor at the University of Massachusetts in Amherst (Chemistry, Food Science & N…
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Here Dr Tan introduces the forms of vitamin E, how they are different and why this matters. He also discusses why a fat based anti-oxidant is required and where alpha tocotrienol is found in nature. Dr. Barrie Tan was formerly an assistant professor at the University of Massachusetts in Amherst (Chemistry, Food Science & Nutrition). His mission at …
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Dr. Nathan Price is the Chief Scientific Officer of Thorne HealthTech. He is co-author with Lee Hood of The Age of Scientific Wellness, and has written articles for The Wall Street Journal, LA Times, and Scientific American. In 2019, he was named one of 10 Emerging Leaders in Health and Medicine by the National Academy of Medicine, and in 2021 he w…
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Here Dr Price talks about some of the things that they learned during the pilot exercises, about biomarkers and the gut microbiome. Dr. Nathan Price is the Chief Scientific Officer of Thorne HealthTech. He is co-author with Lee Hood of The Age of Scientific Wellness, and has written articles for The Wall Street Journal, LA Times, and Scientific Ame…
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We dive into blood biomarkers that help to identify insulin resistance, pre-diabetes and type 2 diabetes and they reasoning behind why these markers are helpful. We then talk about ways to reverse insulin resistance, pre-diabetes and type 2 diabetes. Early detection and slowing down progression of this chronic condition is a great way to preserve h…
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Here Dr Price talks about the concepts of Scientific Wellness and the pilot projects that he and his team ran to try this out. Dr. Nathan Price is the Chief Scientific Officer of Thorne HealthTech. He is co-author with Lee Hood of The Age of Scientific Wellness, and has written articles for The Wall Street Journal, LA Times, and Scientific American…
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Here Prof Kaeberlein talks about where he sees longevity going in the near future. We also talk about personalized medicine and whether it is ready for general use. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life.…
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Here Prof Kaeberlein discusses his thoughts on exercise and diet. In particular he goes into detail on intermittent fasting, time restricted feeding and calorie restriction. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality…
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Diabetes negatively impacts healthspan by increasing the risk of various complications, such as cardiovascular disease, nerve damage, kidney problems, and vision impairment, which can significantly reduce one's overall quality of life as they age. It's a spectrum of disease that starts out with Insulin resistance. Understanding the root cause of In…
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Here Prof Kaeberlein talks about the million molecule challenge and why he thought that it was necessary. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been…
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Here Prof Kaeberlein talks about the Dog Aging Project a study which is following 100,000's of dogs to understand aging better and includes a RTC of rapamycin related to lifespan. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve q…
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Here Prof Kaeberlein talks about the recent paper on taurine deficiency as a driver of aging and makes some comparisons between taurine and rapamycin. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has publis…
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In this introductory episode of The Healthspan Project, we talk about the reason and passion behind creating this podcast. We touch on the importance of proactive care to preserve longevity and healthspan and we also learn a little bit about the host.Anusha Khan, MD
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Here Prof Kaeberlein provides some updates on rapamycin, in particular the results from the survey based trial that his team ran and thoughts on next steps for the supplement. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quali…
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IG: @michaelsalzle. In this episode, we go into the broad topic of exercise. Exercise is considered the most powerful longevity drug. We review studies that underscore the importance of exercise. We also discuss the centenarian decathlon, and take a deep dive into zone 2 training.
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Here we discuss how to measure your gut microbiome, what the future of probiotic and gut microbiome research may hold and what Dr Cutcliffe's personal regimen is. 🌐Links in this video Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, …
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Metabolic Daily is a less potent but more available form of the Glucose Control probiotic used in the clinical trial. Dr Colleen Cutcliffe discusses the differences in the formulations, the best time to take and what effects people have seen 🌐Links in this video Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has mo…
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We talk to Dr Colleen Cutcliffe about a clinical trial that they ran with 5 strains of probiotic. We also talk about whether the strains remained resident and what are the best prebiotics for akkermansia. 🌐Links in this video Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leadin…
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We talk to Dr Colleen Cutcliffe about akkermansia muciniphila a probiotic that is involved in Some links are affiliate links so we will earn a commission when they are used to purchase products. 🌐Links in this video Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and mana…
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This is a bonus extra where we asked Dr Baur for his view on the recent taurine longevity paper as he had written a perspective piece in the same publication - Taurine linked with healthy aging ⁠https://www.science.org/doi/10.1126/science.adi3025⁠ 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us on YouTube 10% D…
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We talk to Dr Joseph Baur about NMNH and NRH and some of the ways that his lab is working on optimizing NAD boosters by trying to get more of the NAD into the mitochondria and testing on larger animals and in humans. 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us on YouTube: https://www.youtube.com/c/modernhea…
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We talk to Dr Joseph Baur about how the NAD precursors are absorbed when administered in different formats and what is seen in the biochemistry after that. And some really weird interaction between mammals and bacteria with nicotinamide/nicotinic acid in the gut. 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us …
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We talk to Dr Joseph Baur about results from trials of NAD boosters in mice and human trials and possible reasons for why the positive results in mice have not translated to humans. 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us on YouTube: https://www.youtube.com/c/modernhealthspan 10% Discount on Renue By Sc…
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We talk to Dr Joseph Baur about how NAD metabolism changes with age, especially the role of NAMPT, the consuming enzymes and NAD boosters. 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us on YouTube: https://www.youtube.com/c/modernhealthspan 10% Discount on Renue By Science products with code MHS https://renueb…
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