Mitochondria, the immune system and cancer: discovering new insights with spatial technologies

Future Science Group

In this episode, supported by Fortis Life Sciences, we delve into the relationship between mitochondria, inflammation and cancer, discussing the new techniques that are bearing fruit in this field, such as spatial analysis. Our expert insight for this episode comes from Phillip West, Principle Investigator of the West lab at Texas A&M Medicine (TX, USA). Philip explains the role mitochondria can play in cancer and heart disease, reveals some of his most exciting discoveries of late and provides technical tips for investigating this field. Listen on to discover how his use of spatial techniques has helped uncover mechanisms linking mitochondrial damage to the stifling of the immune system in the tumor microenvironment and the latest breakthroughs at the intersection of mitochondria and cancer. Contents: Introduction: 00:00-01:30The innate immune system, in inflammation and disease: 01:30-04:20The role of mitochondria in innate immunity: 04:20-07:00Categorizing DAMPS and their role in cardiovascular disease: 07:00-08:40Mitochondria and cancer: 08:40-11:55Techniques for the investigation of mitochondria: 11:55-15:20Best practice techniques for spatial studies: 15:20-17:35Discoveries made using spatial approaches to mitochondrial investigations: 17:35-19:55The latest developments in the intersection of mitochondria, cancer and inflammation: 19:55-22:20What is one thing you would ask for to improve your understanding of this field? 22:20-24:20