49. Penicillin Allergy 2: Delabel Harder

ID:IOTS - Infectious Disease Insight Of Two Specialists

Welcome to the party pal! The penicillin allergy assessment and delabelling party, that is. Callum takes Jame through the latest evidence base in antibiotic allergy in general, and beta lactam allergy assessment and management in particular.
Links:
PENFAST Score paper:
Trubiano JA et al. Development and Validation of a Penicillin Allergy Clinical Decision Rule. doi: 10.1001/jamainternmed.2020.0403.
Sulfonamide allergy paper here (couldn't find anything published more recently):
Urbancic KF et al. Taking the challenge: A protocolized approach to optimize Pneumocystis pneumonia prophylaxis in renal transplant recipients. doi:10.1111/ajt.14498
Dutch beta lactam allergy guidelines:
https://swab.nl/en/exec/file/download/192
And finally...
Norvell MR et al. Cefazolin vs. second-line antibiotics for surgical site infection prevention after total joint arthroplasty among patients with a beta-lactam allergy. https://doi.org/10.1093/ofid/ofad224
Yippee Ki-Yay, my delabellers, we'll see you in a fortnight.

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