Will the Science of Exosomes Revolutionize Medicine?

MedEvidence Articles

This week, we dive into the fascinating world of exosomes, the body’s nano-sized delivery drivers and communication hubs. We’ll explore what exosomes are, their role in cell-to-cell communication and healing, and the potential medical applications they offer. These include drug delivery, regenerative medicine, and combating diseases like cancer and viral infections. We’ll also discuss the challenges scientists face in harnessing exosomes for safe and effective therapies and why clinical trials are essential in uncovering their true potential. Tune in to learn how these tiny biological packages could shape the future of medicine.
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References:

Santos, P., & Almeida, F. (2021). Exosome-based vaccines: history, current state, and clinical trials. Frontiers in immunology, 12, 711565. https://pmc.ncbi.nlm.nih.gov/articles/PMC8317489/

Lee, K. W. A., Chan, L. K. W., Hung, L. C., Phoebe, L. K. W., Park, Y., & Yi, K. H. (2024). Clinical applications of exosomes: a critical review. International Journal of Molecular Sciences, 25(14), 7794. https://pmc.ncbi.nlm.nih.gov/articles/PMC11277529/

Hu, Q., Su, H., Li, J., Lyon, C., Tang, W., Wan, M., & Hu, T. Y. (2020). Clinical applications of exosome membrane proteins. Precision Clinical Medicine, 3(1), 54-66. https://pmc.ncbi.nlm.nih.gov/articles/PMC7099650/

Gurunathan, S., Kang, M. H., & Kim, J. H. (2021). A comprehensive review on factors influences biogenesis, functions, therapeutic and clinical implications of exosomes. International journal of nanomedicine, 1281-1312. https://pmc.ncbi.nlm.nih.gov/articles/PMC7898217/

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Food and DrugAdministration. (6 December, 2019). Public safety notification on exosome products. Safety & availability (biologics). [Website]. Accessed 4 December, 2024. https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/public-safety-notification-exosome-products

Food and DrugAdministration. (9 April, 2024). Consumer alert on regenerative medicine products including stem cells and exosomes. Safety & availability (biologics). [Website]. Accessed 4 December, 2024. https://www.fda.gov/vaccines-blood-biologics/consumers-biologics/consumer-alert-regenerative-medicine-products-including-stem-cells-and-exosomes