Ep. 16: Understanding HNE, Biomarkers, and LPO—with Matt Quinn and Dr. Brian Kerley

Tucker Goodrich: Debugging Life

Introduction

We look at a paper about the process of how the fats in seed oils become toxic, and what effects those toxins can have.

This paper is a broad overview of the related disease processes, which we will discuss to further understand how one thing can be driving many different disease processes.

“The study of lipid peroxidation (LPO) processes has become a rapidly growing field in medicine and biology, based on increasing evidence that LPO is involved in the development of many chronic diseases, e.g. [references removed]

(1) Asthma

(2) Atherosclerosis

(3) Alzheimer’s disease

(4) Rheumatoid arthritis

(5) Burn injury

(6) Cataractogenesis

(7) Diabetes

(8) Endotoxin liver injury

(9) Multiple sclerosis

(10)Myocardial infarction

(11)Organ transplantation

(12)Parkinson disease

(13)Psoriasis

(14)Reperfusion injury

(15)Stroke

(16)Aging

“The obvious involvement of LPO processes in the majority of severe diseases stimulated worldwide efforts to elucidate the mechanisms of their generation.

“These efforts are expressed in the exploding flood of papers, conference reports, review articles (see above) and books dealing with LPO. This paper is, therefore, not intended to add to these reviews but rather to address aspects previously overlooked: the dominant role of linoleic acid (LA) in LPO and the application of a combination of modern separation and identification techniques to isolate LPO products. Knowledge of these products provides insight into the mechanisms of their generation and offers a better understanding of the diseases in which LPO is involved.” (Spiteller 1998)

Guest info

Matt Quinn

https://twitter.com/Mqsley

https://www.mquinn.online/

Biography:

TL;DR Here's what I am working on:

I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here​

I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this

I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here

In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here

I have failed at so so so many things - read about them here

https://www.mquinn.online/

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Co-host

Dr. Brian Kerley

https://www.seedoilrebellion.com/

https://twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?

Check out the Seedy app!

https://www.seedyapp.com/

Tucker Goodrich

Substack: https://tuckergoodrich.substack.com/

Twitter: https://twitter.com/TuckerGoodrich

Youtube: https://www.youtube.com/tuckergoodrich0

Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825

Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y

Podcast: https://sites.libsyn.com/408758

Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/

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Show Notes

Episode 14 Post Script: Matt Has a Surprising Easter Egg

https://youtu.be/1D17vUvbHhk

Spiteller, G. (1998). Linoleic Acid Peroxidation—The Dominant Lipid Peroxidation Process in Low Density Lipoprotein—And Its Relationship to Chronic Diseases. Chemistry and Physics of Lipids, 95(2), 105–162. https://doi.org/10.1016/S0009-3084(98)00091-7

If you have any questions about sources for things discussed please ask in the comments.