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Genetic Tests Identify Risk of Irinotecan-Induced Toxicity: John Logan Black, M.D.
Manage episode 449723859 series 2908385
Контент предоставлен Mayo Clinic Laboratories. Весь контент подкастов, включая эпизоды, графику и описания подкастов, загружается и предоставляется непосредственно компанией Mayo Clinic Laboratories или ее партнером по платформе подкастов. Если вы считаете, что кто-то использует вашу работу, защищенную авторским правом, без вашего разрешения, вы можете выполнить процедуру, описанную здесь https://ru.player.fm/legal.
John Logan Black, M.D., explains how Mayo Clinic Laboratories' UGT1A1 tests (Mayo IDs: U1A1Q and UGTFZ) identify genetic variants that increase the risk of potentially life-threatening reactions to irinotecan, a chemotherapy agent.
Speaker 3: (00:32)
Could you give us a brief overview about your background and yourself?
Speaker 3: (02:16)
Could you explain the role of the UGT1A1 gene and its significance in the pharmacogenomics of irinotecan?
Speaker 3: (05:34)
What specific tests do we offer for UGT1A1 at Mayo Clinic Laboratories?
Speaker 3: (08:01)
Can you clarify the difference between targeted genotyping and full gene sequencing, and when each method is most appropriate?
Speaker 3: (10:36)
Could you elaborate on the specific clinical indications for testing in relation to irinotecan?
Speaker 3: (13:27)
How do UGT1A1 test results impact the dosing of irinotecan? What should clinicians consider when using those results?
Speaker 3: (14:02)
Are there any other factors or related genes that should be considered alongside UGT1A1, particularly for cancer therapy?
333 эпизодов
Поделиться
Manage episode 449723859 series 2908385
Контент предоставлен Mayo Clinic Laboratories. Весь контент подкастов, включая эпизоды, графику и описания подкастов, загружается и предоставляется непосредственно компанией Mayo Clinic Laboratories или ее партнером по платформе подкастов. Если вы считаете, что кто-то использует вашу работу, защищенную авторским правом, без вашего разрешения, вы можете выполнить процедуру, описанную здесь https://ru.player.fm/legal.
John Logan Black, M.D., explains how Mayo Clinic Laboratories' UGT1A1 tests (Mayo IDs: U1A1Q and UGTFZ) identify genetic variants that increase the risk of potentially life-threatening reactions to irinotecan, a chemotherapy agent.
Speaker 3: (00:32)
Could you give us a brief overview about your background and yourself?
Speaker 3: (02:16)
Could you explain the role of the UGT1A1 gene and its significance in the pharmacogenomics of irinotecan?
Speaker 3: (05:34)
What specific tests do we offer for UGT1A1 at Mayo Clinic Laboratories?
Speaker 3: (08:01)
Can you clarify the difference between targeted genotyping and full gene sequencing, and when each method is most appropriate?
Speaker 3: (10:36)
Could you elaborate on the specific clinical indications for testing in relation to irinotecan?
Speaker 3: (13:27)
How do UGT1A1 test results impact the dosing of irinotecan? What should clinicians consider when using those results?
Speaker 3: (14:02)
Are there any other factors or related genes that should be considered alongside UGT1A1, particularly for cancer therapy?
333 эпизодов
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Похожие на Answers from the Lab
Artificial Intelligence has suddenly gone from the fringes of science to being everywhere. So how did we get here? And where's this all heading? In this new series of Science Friction, we're finding out.
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Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
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